{"id":3475,"date":"2025-06-03T11:41:09","date_gmt":"2025-06-03T06:11:09","guid":{"rendered":"https:\/\/uat.myanimal.in\/?post_type=product&#038;p=3475"},"modified":"2025-08-13T11:52:15","modified_gmt":"2025-08-13T06:22:15","slug":"zoletil","status":"publish","type":"product","link":"https:\/\/uat.myanimal.in\/product\/zoletil\/","title":{"rendered":"Zoletil\u2122"},"content":{"rendered":"Zoletil\u2122 comprises a synergistic balance between Tiletamine &amp; Zolazepam. Tiletamine \u2013 a dissociative anesthetic. Zolazepam \u2013 a benzodiazepine tranquilizer group of drugs.\r\n<strong>Recommended for<\/strong>\r\n&#8211; As a sedative (for restraint, diagnostic or painless examination procedures)\r\n&#8211; As a sole anesthetic for minor surgeries or in combination with a potent analgesic for major surgeries\r\n&#8211; As an induction agent, prior to inhalant anesthesia\r\n\r\nWith two proven ingredients, Zoletil\u2122 is a smart option for general anesthesia combining sedation, muscle relaxation, and analgesia in dogs and cats. Zoletil\u2122 offers peace of mind owing to its rapid onset of action, the smooth recovery process, and wide safety margin. With the use of Zoletil\u2122 comes the convenience of flexible dosing based on the procedure to be conducted, multiple modes of administration \u2013 IV or IM, and the possibility to integrate Zoletil\u2122 into existing anesthetic protocols. In addition to the 30 years of experience with Zoletil\u2122 in small animal practice, Zoletil\u2122 has versatility and scientific recognition in a plethora of wildlife species.\r\n\r\n<strong>Composition<\/strong>:\r\nZoletil\u2122 50 = One vial of 675 mg freeze-dried powder contains:\r\nTiletamine (as Hydrochloride) 125 mg\r\nZolazepam (as Hydrochloride) 125 mg\r\nExcipients qs\r\n\r\nONE VIAL OF 5 ML SOLVENT CONTAINS:\r\nSterile Water for injections lP 5 ml\r\n\r\nONE ML OF RECONSTITUTED SOLUTION CONTAINS:\r\nTiletamine (as Hydrochloride) 25 mg\r\nZolazepam (as Hydrochloride) 25 mg\r\n\r\nZoletil\u2122 100 = One vial of 970 mg freeze-dried powder contains:\r\nTiletamine (as Hydrochloride) 250 mg\r\nZolazepam (as Hydrochloride) 250 mg\r\nExcipients qs\r\n\r\nONE VIAL OF 5 ML SOLVENT CONTAINS:\r\nSterile Water for injections lP 5 ml\r\n\r\nONE ML OF RECONSTITUTED SOLUTION CONTAINS:\r\nTiletamine (as Hydrochloride) 50 mg\r\nZolazepam (as Hydrochloride) 50 mg\r\n<p class=\"content-sub-title\"><strong>Dosage and Direction for use<\/strong>:<\/p>\r\n\r\n<table style=\"height: 101px;\" border=\"1\" width=\"809\" cellspacing=\"0\" cellpadding=\"0\">\r\n<tbody>\r\n<tr>\r\n<td>In Dogs<\/td>\r\n<td><strong>Intramuscular route<\/strong><\/td>\r\n<td><strong>Intravenous route<\/strong><\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Tests and procedures causing little pain<\/td>\r\n<td>7 to 10 mg\/kg BW<\/td>\r\n<td>5 mg\/kg BW<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Minor surgical procedures, anaesthesia of short duration<\/td>\r\n<td>10 to 15 mg\/kg BW<\/td>\r\n<td>7.5 mg\/kg BW<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Painful intervention, major surgical procedures<\/td>\r\n<td>15 to 25 mg\/kg BW<\/td>\r\n<td>10 mg\/kg BW<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n&nbsp;\r\n<table style=\"height: 78px;\" border=\"1\" width=\"715\" cellspacing=\"0\" cellpadding=\"0\">\r\n<tbody>\r\n<tr>\r\n<td>In Cats<\/td>\r\n<td><strong>Intramuscular route<\/strong><\/td>\r\n<td><strong>Intravenous route<\/strong><\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Tests and procedures causing little pain<\/td>\r\n<td>10 mg\/kg BW<\/td>\r\n<td>5 mg\/kg BW<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Surgeries<\/td>\r\n<td>15 mg\/kg BW<\/td>\r\n<td>7.5 mg\/kg BW<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\nMultiple administrations to be avoided and is associated with delayed recovery, but if given, re-administration should only be at 1\/3 to \u00bd of the initial dose, but the total dosage is should not exceed 26.4 mg\/kg.\r\n\r\n<strong>Storage<\/strong>:\r\nPrior to opening store in a cool &amp; dry place, protect from exposure to light. Post-re-constitution store at 2 to 8\u00b0C and use within 24 hours.\r\n\r\n<strong>Suggestions<\/strong>:\r\n12 hours of fasting prior to anesthesia\r\nRemoval of anti-parasite collars 24 hours prior to anesthesia\r\nAnticholinergic drugs (such as Atropine) may be used 15 mins. prior to Zoletil\u2122 administration\r\nApneustic breathing may be observed in cats given in IV mode. This abnormality may last for up to 15 mins &amp; then breathing returns to normal. If not, respiratory assistance needs to be provided.\r\nEyes remain open and hence should be protected from excessive dryness (especially in major surgeries, a damp cloth can be placed upon the eyes)\r\nAnimal to be placed in a calm environment during the recovery phase\r\n\r\n<strong>Contraindications<\/strong>:\r\nCardiac disease or severe hypertension; respiratory disease; renal, pancreatic, and hepatic insufficiency; head trauma or intracranial tumors\r\nCaesarean section or in pregnant bitches and queens\r\nIn conjunction with phenothiazine tranquilizers\r\n\r\n<strong>Warnings<\/strong>: For use in dogs and cats only.\r\n\r\nWhen using Zoletil for Injection for induction of anesthesia, patients should be continuously monitored. Facilities for the maintenance of a patent airway, artificial ventilation and oxygen supplementation should be available.\r\n\r\nPulmonary edema has been reported to occur in cats with the use of tiletamine and zolazepam for injection. Signs and symptoms include dyspnea, lethargy, anorexia and abnormal behavior. Deaths have been reported occasionally in severely affected individuals. Cats should be observed closely for any signs and symptoms which may suggest pulmonary edema so that appropriate therapy may be instituted.\r\n\r\nThe principal route of excretion of both components in the cat is the urine; therefore, Zoletil for Injection is not recommended for use in cats suffering from renal insufficiency.\r\n\r\nBalance studies in dogs indicated extensive biotransformation of both components with less than 4% of the dose excreted unchanged in the urine.\r\n\r\nZoletil for Injection is excreted predominantly by the kidneys. Preexistent renal pathology or impairment of renal function may be expected to result in prolonged duration of anesthesia.\r\n\r\nPhenothiazine-derivative drugs should not be used with Zoletil for Injection at dosages indicated for intramuscular (IM) injection because the combination produces respiratory and myocardial depression, hypotension and hypothermia.\r\n\r\nThe safe use of Zoletil for Injection in pregnant animals or on reproduction has not been established. Zoletil for Injection crosses the placental barrier and causes respiratory depression in the neonate.\r\n\r\n<strong>Precautions<\/strong>:\r\n\r\nThe dosage of Zoletil for Injection should be reduced in geriatric dogs and cats, in animals in debilitated condition and in animals with impairment of renal function. Death has occurred in both cats and dogs following intramuscular tiletamine and zolazepam for injection administration. Preexisting pulmonary disease, renal disease (see Contraindications and Warnings) and shock were causally implicated at necropsy; however, death was drug attributable in at least one dog (of 1072) and one cat (of 1095).\r\n\r\nIntravenous tiletamine and zolazepam for injection has been demonstrated to be safe in a field study in dogs when used in conjunction with phenothiazine-derivative drugs (acepromazine) administered at dosages from 0.04-0.06 mg\/kg IM.\r\n\r\nCats and smaller dogs with small body masses in relation to large body surfaces should be protected from heat loss during Zoletil for Injection anesthesia. Body temperature should be monitored, and supplemental heat may be required to control hypothermia. As with other anesthetics, it is prudent to provide for hemostasis during any surgical procedure.\r\n\r\nDuring Zoletil for Injection anesthesia, athetoid movement may occur. This athetosis should not be mistaken for lack of anesthesia nor is it indicative of lack of analgesia. Do not give additional anesthesia in an attempt to abolish the athetoid movement. Efforts to eliminate athetoid movement with additional doses of Zoletil for Injection can result in anesthetic overdosage.\r\n\r\nZoletil for Injection does not abolish laryngeal, pharyngeal, pinnal, palpebral, and pedal reflexes, and may not be adequate as the sole anesthetic for surgical procedures in these areas. Endotracheal tubes are not well tolerated in connection with Zoletil for Injection anesthesia in the cat and their use may result in impaired respiration. After removal of the tube, normal respiration should resume.\r\n\r\nThe stimulation of surgical procedures aids in maintaining adequate ventilation. The anesthetized patient must be monitored throughout the procedure, and if cardiopulmonary problems do occur, measures must be taken to assure that alveolar ventilation and cardiovascular functions are maintained.\r\n\r\nThe eyes normally remain open with the pupils dilated. The use of a bland ophthalmic ointment is advisable to protect the corneas from desiccation. The concurrent use of chloramphenicol will prolong the duration of anesthesia in cats.\r\n\r\nCopious salivation may occur during Zoletil for Injection anesthesia. Ptyalism may be controlled in dogs and cats by administering atropine sulfate, USP, 0.02 mg\/lb (0.04 mg\/kg) body weight (IV, IM, or SC) as concurrent medication. Exaggerated swallowing, reflex action and accumulation of saliva may give rise to vomiting and retching.","protected":false},"excerpt":{"rendered":"<p>Zoletil\u2122 for Injection (tiletamine and zolazepam) is a non-narcotic, non-barbiturate injectable anesthetic for dogs and cats. It combines tiletamine, a dissociative anesthetic, with zolazepam, a tranquilizer. Supplied sterile in vials, it is reconstituted with 5 mL diluent to yield a solution containing 50 mg\/mL of each active ingredient, along with mannitol. The solution (pH 2\u20133.5) is recommended for deep intramuscular injection.<\/p>\n","protected":false},"featured_media":3476,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[35,36,18,141,235,27],"product_tag":[],"class_list":{"0":"post-3475","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-cat-products","7":"product_cat-dog-products","8":"product_cat-pets","9":"product_cat-dog-pharmacy","10":"product_cat-cat-pharmacy","11":"product_cat-pharmacy","13":"first","14":"instock","15":"taxable","16":"shipping-taxable","17":"purchasable","18":"product-type-simple"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>MyAnimal - Zoletil\u2122<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MyAnimal - Zoletil\u2122\" \/>\n<meta property=\"og:description\" content=\"Zoletil\u2122 for Injection (tiletamine and zolazepam) is a non-narcotic, non-barbiturate injectable anesthetic for dogs and cats. 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